kpc mice Search Results


kpc mice  (Jackson Laboratory)
90
Jackson Laboratory kpc mice
Kpc Mice, supplied by Jackson Laboratory, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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kpc transgenic mice  (Cyagen Biosciences)
90
Cyagen Biosciences kpc transgenic mice
Kpc Transgenic Mice, supplied by Cyagen Biosciences, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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kpc mice  (Cyagen Biosciences)
90
Cyagen Biosciences kpc mice
Kpc Mice, supplied by Cyagen Biosciences, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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kpc mice  (Shanghai Model Organisms Center)
90
Shanghai Model Organisms Center kpc mice
pCAFs enhance PNI of pancreatic cancer via lactate-mediated H3K18la in vivo . A, Gross and surgical images, hematoxylin and eosin (H&E) staining, and mIF images. mIF showed pan-lac, H3K18, L1CAM, and SLIT1 expression in the sciatic nerve invasion model. The dotted line indicates the tumor boundary. Tuj1 served as a neuronal marker, and CK19 was used as a tumor marker. H&E, scale bars, 1,000 μm. mIF, scale bars, 200 μm. B, Sciatic nerve function scores and sciatic nerve indexes of mice treated as indicated ( n = 5 mice per group). Kruskal–Wallis test with Dunn multiple comparisons test; data are shown as the means ± SD. C–E, <t>KPC</t> <t>mice</t> <t>(LSL-</t> KRAS <t>G12D/</t> + ; LSL- <t>TRP53</t> <t>R172H</t> / + ; PDX- 1- CRE +/+ ) were divided into four groups, with three groups respectively receiving i.p. injections of sodium lactate (1 g/kg), oral administration of the MCT1 inhibitor AZD3965 (100 mg/kg), and i.p. injections of heptenoic acid (1 mg/kg). n = 10 mice per group. C, Representative hematoxylin and eosin staining. mIF and 3D reconstruction images showing PNI status and pan-lac, H3K18, L1CAM, and SLIT1 expression in KPC mice treated as indicated. Tuj1 served as a neuron marker. CK19 was used as a tumor marker. Hematoxylin and eosin and mIF, scale bars, 200 μm. 3D scale bars, 500 μm. D, Proportion of PNI in KPC mice under the specified treatments ( n = 10 mice per group). Fisher exact test. E, Nerve density percentage (left) and number (right) in KPC mice following the indicated treatments ( n = 10 mice per group; χ 2 test). *, P < 0.05. HA, heptenoic acid.
Kpc Mice, supplied by Shanghai Model Organisms Center, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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kpc mice-derived cell line  (Cyagen Biosciences)
90
Cyagen Biosciences kpc mice-derived cell line
pCAFs enhance PNI of pancreatic cancer via lactate-mediated H3K18la in vivo . A, Gross and surgical images, hematoxylin and eosin (H&E) staining, and mIF images. mIF showed pan-lac, H3K18, L1CAM, and SLIT1 expression in the sciatic nerve invasion model. The dotted line indicates the tumor boundary. Tuj1 served as a neuronal marker, and CK19 was used as a tumor marker. H&E, scale bars, 1,000 μm. mIF, scale bars, 200 μm. B, Sciatic nerve function scores and sciatic nerve indexes of mice treated as indicated ( n = 5 mice per group). Kruskal–Wallis test with Dunn multiple comparisons test; data are shown as the means ± SD. C–E, <t>KPC</t> <t>mice</t> <t>(LSL-</t> KRAS <t>G12D/</t> + ; LSL- <t>TRP53</t> <t>R172H</t> / + ; PDX- 1- CRE +/+ ) were divided into four groups, with three groups respectively receiving i.p. injections of sodium lactate (1 g/kg), oral administration of the MCT1 inhibitor AZD3965 (100 mg/kg), and i.p. injections of heptenoic acid (1 mg/kg). n = 10 mice per group. C, Representative hematoxylin and eosin staining. mIF and 3D reconstruction images showing PNI status and pan-lac, H3K18, L1CAM, and SLIT1 expression in KPC mice treated as indicated. Tuj1 served as a neuron marker. CK19 was used as a tumor marker. Hematoxylin and eosin and mIF, scale bars, 200 μm. 3D scale bars, 500 μm. D, Proportion of PNI in KPC mice under the specified treatments ( n = 10 mice per group). Fisher exact test. E, Nerve density percentage (left) and number (right) in KPC mice following the indicated treatments ( n = 10 mice per group; χ 2 test). *, P < 0.05. HA, heptenoic acid.
Kpc Mice Derived Cell Line, supplied by Cyagen Biosciences, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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spf grade icr full-male mice  (KPC Pharmaceuticals Inc)
90
KPC Pharmaceuticals Inc spf grade icr full-male mice
pCAFs enhance PNI of pancreatic cancer via lactate-mediated H3K18la in vivo . A, Gross and surgical images, hematoxylin and eosin (H&E) staining, and mIF images. mIF showed pan-lac, H3K18, L1CAM, and SLIT1 expression in the sciatic nerve invasion model. The dotted line indicates the tumor boundary. Tuj1 served as a neuronal marker, and CK19 was used as a tumor marker. H&E, scale bars, 1,000 μm. mIF, scale bars, 200 μm. B, Sciatic nerve function scores and sciatic nerve indexes of mice treated as indicated ( n = 5 mice per group). Kruskal–Wallis test with Dunn multiple comparisons test; data are shown as the means ± SD. C–E, <t>KPC</t> <t>mice</t> <t>(LSL-</t> KRAS <t>G12D/</t> + ; LSL- <t>TRP53</t> <t>R172H</t> / + ; PDX- 1- CRE +/+ ) were divided into four groups, with three groups respectively receiving i.p. injections of sodium lactate (1 g/kg), oral administration of the MCT1 inhibitor AZD3965 (100 mg/kg), and i.p. injections of heptenoic acid (1 mg/kg). n = 10 mice per group. C, Representative hematoxylin and eosin staining. mIF and 3D reconstruction images showing PNI status and pan-lac, H3K18, L1CAM, and SLIT1 expression in KPC mice treated as indicated. Tuj1 served as a neuron marker. CK19 was used as a tumor marker. Hematoxylin and eosin and mIF, scale bars, 200 μm. 3D scale bars, 500 μm. D, Proportion of PNI in KPC mice under the specified treatments ( n = 10 mice per group). Fisher exact test. E, Nerve density percentage (left) and number (right) in KPC mice following the indicated treatments ( n = 10 mice per group; χ 2 test). *, P < 0.05. HA, heptenoic acid.
Spf Grade Icr Full Male Mice, supplied by KPC Pharmaceuticals Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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pancreatic tumor and organ tissues of gemm kpc mice  (Purdue University Cytometry)
90
Purdue University Cytometry pancreatic tumor and organ tissues of gemm kpc mice
pCAFs enhance PNI of pancreatic cancer via lactate-mediated H3K18la in vivo . A, Gross and surgical images, hematoxylin and eosin (H&E) staining, and mIF images. mIF showed pan-lac, H3K18, L1CAM, and SLIT1 expression in the sciatic nerve invasion model. The dotted line indicates the tumor boundary. Tuj1 served as a neuronal marker, and CK19 was used as a tumor marker. H&E, scale bars, 1,000 μm. mIF, scale bars, 200 μm. B, Sciatic nerve function scores and sciatic nerve indexes of mice treated as indicated ( n = 5 mice per group). Kruskal–Wallis test with Dunn multiple comparisons test; data are shown as the means ± SD. C–E, <t>KPC</t> <t>mice</t> <t>(LSL-</t> KRAS <t>G12D/</t> + ; LSL- <t>TRP53</t> <t>R172H</t> / + ; PDX- 1- CRE +/+ ) were divided into four groups, with three groups respectively receiving i.p. injections of sodium lactate (1 g/kg), oral administration of the MCT1 inhibitor AZD3965 (100 mg/kg), and i.p. injections of heptenoic acid (1 mg/kg). n = 10 mice per group. C, Representative hematoxylin and eosin staining. mIF and 3D reconstruction images showing PNI status and pan-lac, H3K18, L1CAM, and SLIT1 expression in KPC mice treated as indicated. Tuj1 served as a neuron marker. CK19 was used as a tumor marker. Hematoxylin and eosin and mIF, scale bars, 200 μm. 3D scale bars, 500 μm. D, Proportion of PNI in KPC mice under the specified treatments ( n = 10 mice per group). Fisher exact test. E, Nerve density percentage (left) and number (right) in KPC mice following the indicated treatments ( n = 10 mice per group; χ 2 test). *, P < 0.05. HA, heptenoic acid.
Pancreatic Tumor And Organ Tissues Of Gemm Kpc Mice, supplied by Purdue University Cytometry, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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kpc female mice  (Cyagen Biosciences)
90
Cyagen Biosciences kpc female mice
pCAFs enhance PNI of pancreatic cancer via lactate-mediated H3K18la in vivo . A, Gross and surgical images, hematoxylin and eosin (H&E) staining, and mIF images. mIF showed pan-lac, H3K18, L1CAM, and SLIT1 expression in the sciatic nerve invasion model. The dotted line indicates the tumor boundary. Tuj1 served as a neuronal marker, and CK19 was used as a tumor marker. H&E, scale bars, 1,000 μm. mIF, scale bars, 200 μm. B, Sciatic nerve function scores and sciatic nerve indexes of mice treated as indicated ( n = 5 mice per group). Kruskal–Wallis test with Dunn multiple comparisons test; data are shown as the means ± SD. C–E, <t>KPC</t> <t>mice</t> <t>(LSL-</t> KRAS <t>G12D/</t> + ; LSL- <t>TRP53</t> <t>R172H</t> / + ; PDX- 1- CRE +/+ ) were divided into four groups, with three groups respectively receiving i.p. injections of sodium lactate (1 g/kg), oral administration of the MCT1 inhibitor AZD3965 (100 mg/kg), and i.p. injections of heptenoic acid (1 mg/kg). n = 10 mice per group. C, Representative hematoxylin and eosin staining. mIF and 3D reconstruction images showing PNI status and pan-lac, H3K18, L1CAM, and SLIT1 expression in KPC mice treated as indicated. Tuj1 served as a neuron marker. CK19 was used as a tumor marker. Hematoxylin and eosin and mIF, scale bars, 200 μm. 3D scale bars, 500 μm. D, Proportion of PNI in KPC mice under the specified treatments ( n = 10 mice per group). Fisher exact test. E, Nerve density percentage (left) and number (right) in KPC mice following the indicated treatments ( n = 10 mice per group; χ 2 test). *, P < 0.05. HA, heptenoic acid.
Kpc Female Mice, supplied by Cyagen Biosciences, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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kpc mice  (Cold Spring Harbor Laboratory Meetings)
90
Cold Spring Harbor Laboratory Meetings kpc mice
pCAFs enhance PNI of pancreatic cancer via lactate-mediated H3K18la in vivo . A, Gross and surgical images, hematoxylin and eosin (H&E) staining, and mIF images. mIF showed pan-lac, H3K18, L1CAM, and SLIT1 expression in the sciatic nerve invasion model. The dotted line indicates the tumor boundary. Tuj1 served as a neuronal marker, and CK19 was used as a tumor marker. H&E, scale bars, 1,000 μm. mIF, scale bars, 200 μm. B, Sciatic nerve function scores and sciatic nerve indexes of mice treated as indicated ( n = 5 mice per group). Kruskal–Wallis test with Dunn multiple comparisons test; data are shown as the means ± SD. C–E, <t>KPC</t> <t>mice</t> <t>(LSL-</t> KRAS <t>G12D/</t> + ; LSL- <t>TRP53</t> <t>R172H</t> / + ; PDX- 1- CRE +/+ ) were divided into four groups, with three groups respectively receiving i.p. injections of sodium lactate (1 g/kg), oral administration of the MCT1 inhibitor AZD3965 (100 mg/kg), and i.p. injections of heptenoic acid (1 mg/kg). n = 10 mice per group. C, Representative hematoxylin and eosin staining. mIF and 3D reconstruction images showing PNI status and pan-lac, H3K18, L1CAM, and SLIT1 expression in KPC mice treated as indicated. Tuj1 served as a neuron marker. CK19 was used as a tumor marker. Hematoxylin and eosin and mIF, scale bars, 200 μm. 3D scale bars, 500 μm. D, Proportion of PNI in KPC mice under the specified treatments ( n = 10 mice per group). Fisher exact test. E, Nerve density percentage (left) and number (right) in KPC mice following the indicated treatments ( n = 10 mice per group; χ 2 test). *, P < 0.05. HA, heptenoic acid.
Kpc Mice, supplied by Cold Spring Harbor Laboratory Meetings, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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kpc mice  (Wolters Kluwer Health)
90
Wolters Kluwer Health kpc mice
pCAFs enhance PNI of pancreatic cancer via lactate-mediated H3K18la in vivo . A, Gross and surgical images, hematoxylin and eosin (H&E) staining, and mIF images. mIF showed pan-lac, H3K18, L1CAM, and SLIT1 expression in the sciatic nerve invasion model. The dotted line indicates the tumor boundary. Tuj1 served as a neuronal marker, and CK19 was used as a tumor marker. H&E, scale bars, 1,000 μm. mIF, scale bars, 200 μm. B, Sciatic nerve function scores and sciatic nerve indexes of mice treated as indicated ( n = 5 mice per group). Kruskal–Wallis test with Dunn multiple comparisons test; data are shown as the means ± SD. C–E, <t>KPC</t> <t>mice</t> <t>(LSL-</t> KRAS <t>G12D/</t> + ; LSL- <t>TRP53</t> <t>R172H</t> / + ; PDX- 1- CRE +/+ ) were divided into four groups, with three groups respectively receiving i.p. injections of sodium lactate (1 g/kg), oral administration of the MCT1 inhibitor AZD3965 (100 mg/kg), and i.p. injections of heptenoic acid (1 mg/kg). n = 10 mice per group. C, Representative hematoxylin and eosin staining. mIF and 3D reconstruction images showing PNI status and pan-lac, H3K18, L1CAM, and SLIT1 expression in KPC mice treated as indicated. Tuj1 served as a neuron marker. CK19 was used as a tumor marker. Hematoxylin and eosin and mIF, scale bars, 200 μm. 3D scale bars, 500 μm. D, Proportion of PNI in KPC mice under the specified treatments ( n = 10 mice per group). Fisher exact test. E, Nerve density percentage (left) and number (right) in KPC mice following the indicated treatments ( n = 10 mice per group; χ 2 test). *, P < 0.05. HA, heptenoic acid.
Kpc Mice, supplied by Wolters Kluwer Health, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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kpc mice cat. no. nm-ki-210096  (Shanghai Model Organisms Center)
90
Shanghai Model Organisms Center kpc mice cat. no. nm-ki-210096
pCAFs enhance PNI of pancreatic cancer via lactate-mediated H3K18la in vivo . A, Gross and surgical images, hematoxylin and eosin (H&E) staining, and mIF images. mIF showed pan-lac, H3K18, L1CAM, and SLIT1 expression in the sciatic nerve invasion model. The dotted line indicates the tumor boundary. Tuj1 served as a neuronal marker, and CK19 was used as a tumor marker. H&E, scale bars, 1,000 μm. mIF, scale bars, 200 μm. B, Sciatic nerve function scores and sciatic nerve indexes of mice treated as indicated ( n = 5 mice per group). Kruskal–Wallis test with Dunn multiple comparisons test; data are shown as the means ± SD. C–E, <t>KPC</t> <t>mice</t> <t>(LSL-</t> KRAS <t>G12D/</t> + ; LSL- <t>TRP53</t> <t>R172H</t> / + ; PDX- 1- CRE +/+ ) were divided into four groups, with three groups respectively receiving i.p. injections of sodium lactate (1 g/kg), oral administration of the MCT1 inhibitor AZD3965 (100 mg/kg), and i.p. injections of heptenoic acid (1 mg/kg). n = 10 mice per group. C, Representative hematoxylin and eosin staining. mIF and 3D reconstruction images showing PNI status and pan-lac, H3K18, L1CAM, and SLIT1 expression in KPC mice treated as indicated. Tuj1 served as a neuron marker. CK19 was used as a tumor marker. Hematoxylin and eosin and mIF, scale bars, 200 μm. 3D scale bars, 500 μm. D, Proportion of PNI in KPC mice under the specified treatments ( n = 10 mice per group). Fisher exact test. E, Nerve density percentage (left) and number (right) in KPC mice following the indicated treatments ( n = 10 mice per group; χ 2 test). *, P < 0.05. HA, heptenoic acid.
Kpc Mice Cat. No. Nm Ki 210096, supplied by Shanghai Model Organisms Center, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Image Search Results


pCAFs enhance PNI of pancreatic cancer via lactate-mediated H3K18la in vivo . A, Gross and surgical images, hematoxylin and eosin (H&E) staining, and mIF images. mIF showed pan-lac, H3K18, L1CAM, and SLIT1 expression in the sciatic nerve invasion model. The dotted line indicates the tumor boundary. Tuj1 served as a neuronal marker, and CK19 was used as a tumor marker. H&E, scale bars, 1,000 μm. mIF, scale bars, 200 μm. B, Sciatic nerve function scores and sciatic nerve indexes of mice treated as indicated ( n = 5 mice per group). Kruskal–Wallis test with Dunn multiple comparisons test; data are shown as the means ± SD. C–E, KPC mice (LSL- KRAS G12D/ + ; LSL- TRP53 R172H / + ; PDX- 1- CRE +/+ ) were divided into four groups, with three groups respectively receiving i.p. injections of sodium lactate (1 g/kg), oral administration of the MCT1 inhibitor AZD3965 (100 mg/kg), and i.p. injections of heptenoic acid (1 mg/kg). n = 10 mice per group. C, Representative hematoxylin and eosin staining. mIF and 3D reconstruction images showing PNI status and pan-lac, H3K18, L1CAM, and SLIT1 expression in KPC mice treated as indicated. Tuj1 served as a neuron marker. CK19 was used as a tumor marker. Hematoxylin and eosin and mIF, scale bars, 200 μm. 3D scale bars, 500 μm. D, Proportion of PNI in KPC mice under the specified treatments ( n = 10 mice per group). Fisher exact test. E, Nerve density percentage (left) and number (right) in KPC mice following the indicated treatments ( n = 10 mice per group; χ 2 test). *, P < 0.05. HA, heptenoic acid.

Journal: Cancer Research

Article Title: Cancer-Associated Fibroblasts Foster a High-Lactate Microenvironment to Drive Perineural Invasion in Pancreatic Cancer

doi: 10.1158/0008-5472.CAN-24-3173

Figure Lengend Snippet: pCAFs enhance PNI of pancreatic cancer via lactate-mediated H3K18la in vivo . A, Gross and surgical images, hematoxylin and eosin (H&E) staining, and mIF images. mIF showed pan-lac, H3K18, L1CAM, and SLIT1 expression in the sciatic nerve invasion model. The dotted line indicates the tumor boundary. Tuj1 served as a neuronal marker, and CK19 was used as a tumor marker. H&E, scale bars, 1,000 μm. mIF, scale bars, 200 μm. B, Sciatic nerve function scores and sciatic nerve indexes of mice treated as indicated ( n = 5 mice per group). Kruskal–Wallis test with Dunn multiple comparisons test; data are shown as the means ± SD. C–E, KPC mice (LSL- KRAS G12D/ + ; LSL- TRP53 R172H / + ; PDX- 1- CRE +/+ ) were divided into four groups, with three groups respectively receiving i.p. injections of sodium lactate (1 g/kg), oral administration of the MCT1 inhibitor AZD3965 (100 mg/kg), and i.p. injections of heptenoic acid (1 mg/kg). n = 10 mice per group. C, Representative hematoxylin and eosin staining. mIF and 3D reconstruction images showing PNI status and pan-lac, H3K18, L1CAM, and SLIT1 expression in KPC mice treated as indicated. Tuj1 served as a neuron marker. CK19 was used as a tumor marker. Hematoxylin and eosin and mIF, scale bars, 200 μm. 3D scale bars, 500 μm. D, Proportion of PNI in KPC mice under the specified treatments ( n = 10 mice per group). Fisher exact test. E, Nerve density percentage (left) and number (right) in KPC mice following the indicated treatments ( n = 10 mice per group; χ 2 test). *, P < 0.05. HA, heptenoic acid.

Article Snippet: KPC (LSL-KRAS G12D/+ , LSL-TRP53 R172H/+ , PDX-1-CRE +/+ ) mice were purchased from Shanghai Model Organisms.

Techniques: In Vivo, Staining, Expressing, Marker